Silver Nano-Membrane Kills Microbes in Medical Paper, Nonwoven Filters
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Nanofiber membranes for cellulosic biomedical filtration devices (sheets, fabrics, and nonwovens made by the P&P related industries) require antibacterial activity to prevent bacterial contamination under moisture conditions while exhibiting biocompatibility.
Here, we propose an antibacterial membrane filter composed of electrospun polyacrylonitrile (PAN) nanofibers with a surface functionalized with silver nanoparticles (AgNPs) by a facile wetting process for in situ silver reduction under physiologically mild conditions.
Why Silver?
Metal nanoparticles are being considered as a new class of antibacterial agents due to their high profiled properties, such as physical, chemical and biological properties. Among them, silver and copper exhibit appreciable antibacterial activity against Bacillus subtilis and E-Coli which are the major etiological agents responsible for invasive infections in wounds around the globe
Sequential wetting of thermally stabilized PAN nanofibers in silver nitrate (AgNO3) and sodium hydroxide (NaOH) solutions enabled direct control of the amount of synthesized AgNPs and their release behaviors in an aqueous environment.
The fabricated AgNPs-functionalized PAN nanofibers (PAN-AgNPs) exhibit the appreciable antibacterial efficiency against Escherichia coli and Staphylococcus aureus bacteria with considerable sustainability for repetitive use. In addition, the generated AgNPs on PAN nanofiber membranes in an adequate loading range also revealed good biocompatibility with mammalian cells. Thus, PAN-AgNPs nanofibers can be practically applied as a promising disinfecting membrane filter for biomedical and hygienic applications.
